Correction: Discovery, synthesis and structure–activity analysis of symmetrical 2,7-disubstituted fluorenones as urea transporter inhibitors
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چکیده
منابع مشابه
Urea Transporter Inhibitors as Novel Diuretics
Urea transporter (UT) proteins, including isoforms of UT-A in kidney tubule epithelia and UT-B in vasa recta endothelia and erythrocytes, play an important role in the urine concentration mechanism by mediated an intra renal urea recycling, suggesting that functional inhibition of these proteins could have therapeutic use as a novel class of diuretic. Recently several classes of UT inhibitors h...
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Soluble epoxide hydrolase enzyme is a promising therapeutic target for hypertension, vascular inflammation, pain and some other risk factors of cardiovascular diseases. The most potent sEH inhibitors reported in the literature are urea-based ones which often have poor bioavailability. In this study, in a quest for finding potent inhibitors of soluble epoxide hydrolase, some 4,6-disubstituted py...
متن کاملDesign, Synthesis and Biological Activity of 4,6-disubstituted Pyridin-2(1H)-ones as Novel Inhibitors of Soluble Epoxide Hydrolase
Soluble epoxide hydrolase enzyme is a promising therapeutic target for hypertension, vascular inflammation, pain and some other risk factors of cardiovascular diseases. The most potent sEH inhibitors reported in the literature are urea-based ones which often have poor bioavailability. In this study, in a quest for finding potent inhibitors of soluble epoxide hydrolase, some 4,6-disubstituted py...
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Rapid synthesis of symmetrical 1, 3disubstituted urea derivatives from biuret and different substituted anilines has been carried out in presence of Sodium chloride (NaCl) in dry media. Diverse substituted anilines were reacted with biuret in 2:1 molar ratio to give the corresponding urea derivatives. The reaction conditions were clement, solvent free, mild and the products were attained in goo...
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An effective and eco friendly procedure under microwave irradiation, for synthesis of symmetrical disubstituted alkyl and aryl ureas from amine hydrochlorides using water as solvent medium has been developed. Based on molecular docking studies on HIV-1 gp120, synthesized compounds were evaluated for HIV-1 gp120 – CD4 binding inhibition and these molecules showed micro molar range (0.047 μM to 4...
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ژورنال
عنوان ژورنال: MedChemComm
سال: 2015
ISSN: 2040-2503,2040-2511
DOI: 10.1039/c5md90031j